Hello, I have the almost same problem: Flashplayer (v25 latest version) does not work in a sandboxed Firefox 53 web browser.
My system: Windows 7 64bit Enterprise, Firefox 53/64bit - identified as Mozilla/5.0 (Windows NT 6.1; Win64; x64; rv:53.0) Gecko/20100101 Firefox/53.0
Example of the bug: Start the Firefox 53 in Sandboxie, load the homepage:
http://www.alexo.org/onlinespiele/asteroids2.php
The loading of the game is stuck at 100% ; you cannot play the game.
However, I found a very strange solution: Make a SECOND sandbox, with no special settings, whatsoever, and start the Firefox53/64bit in the SECOND sandbox.
THEN, the game works.
And NO, my first sandbox DOES NOT HAVE any special settings, and every other 32-bit browser DOES work fine with flashplayer in the first sandbox.
But hey, I actually find this bug useful, because, if I want to avoid Flashplayer stuff, I simply use the first sandbox, otherwise the second one.
The sandboxie version I use is 5.12/64bit.
First sandbox:
[DefaultBox]
ConfigLevel=7
Template=PandaCloudAntivirus
Template=Firefox_Session_DirectAccess
Template=Thunderbird
Template=Eudora
Template=BlockPorts
Template=LingerPrograms
Template=Chrome_Phishing_DirectAccess
Template=Firefox_Phishing_DirectAccess
Template=AutoRecoverIgnore
RecoverFolder=%{374DE290-123F-4565-9164-39C4925E467B}%
RecoverFolder=%Personal%
RecoverFolder=%Favorites%
RecoverFolder=%Desktop%
BorderColor=#00FFFF,ttl
Enabled=y
NeverDelete=n
AutoRecover=y
OpenFilePath=firefox.exe,K:\FFCACHE
OpenFilePath=firefox.exe,X:\DOWNLOADS\
ForceProcess=eudora.exe
NotifyInternetAccessDenied=n
NotifyStartRunAccessDenied=y
CopyLimitKb=56008
Second sandbox:
[Sandbox2_Test]
Enabled=y
ConfigLevel=7
AutoRecover=y
Template=WindowsFontCache
Template=BlockPorts
Template=LingerPrograms
Template=Chrome_Phishing_DirectAccess
Template=Firefox_Phishing_DirectAccess
Template=AutoRecoverIgnore
RecoverFolder=%{374DE290-123F-4565-9164-39C4925E467B}%
RecoverFolder=%Personal%
RecoverFolder=%Favorites%
RecoverFolder=%Desktop%
BorderColor=#00FFFF,ttl